-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, Vny5/Q+VNPQn9sc0jRkCtbda0Q0ghJ2YCWXK/dX6rakodRRGz6Yis7nlxa6+kzFR ljPKSCGDh6v5JM9hevhPWw== 0000950142-06-000332.txt : 20060214 0000950142-06-000332.hdr.sgml : 20060214 20060214162656 ACCESSION NUMBER: 0000950142-06-000332 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 4 FILED AS OF DATE: 20060214 DATE AS OF CHANGE: 20060214 GROUP MEMBERS: FRANK H. PEARL GROUP MEMBERS: GEORGE SOROS GROUP MEMBERS: PERSEUS BIOTECH FUND PARTNERS, LLC GROUP MEMBERS: PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP GROUP MEMBERS: PERSEUS-SOROS PARTNERS, LLC GROUP MEMBERS: PERSEUSPUR, LLC GROUP MEMBERS: SFM AH LLC GROUP MEMBERS: SFM PARTICIPATION, L.P. GROUP MEMBERS: SOROS FUND MANAGEMENT LLC SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: BARRIER THERAPEUTICS INC CENTRAL INDEX KEY: 0001173657 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 223828030 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-79875 FILM NUMBER: 06615703 BUSINESS ADDRESS: STREET 1: 600 COLLEGE ROAD EAST STREET 2: SUITE 3200 CITY: PRINCETON STATE: NJ ZIP: 08540 BUSINESS PHONE: 6099451200 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: PERSEUS SOROS BIOPHARMACEUTICAL FUND LP CENTRAL INDEX KEY: 0001111408 IRS NUMBER: 000000000 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: ARMY & NAVY CLUB BLDG STREET 2: 1627 I ST NW STE 610 CITY: WASHINGTON STATE: DC ZIP: 20006 BUSINESS PHONE: (212) 651-6389 MAIL ADDRESS: STREET 1: 888 SEVENTH AVE STREET 2: 30TH FL CITY: NEW YORK STATE: NY ZIP: 10106 SC 13G/A 1 sc13ga1_barrier.txt AMENDMENT NO. 1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* BARRIER THERAPEUTICS, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $.0001 PER SHARE (Title of Class of Securities) 06850R108 (CUSIP Number) DECEMBER 31, 2005 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [_] Rule 13d-1(b) [_] Rule 13d-1(c) [X] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the reminder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP NO. 06850R108 Schedule 13G Page 2 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person Perseus-Soros BioPharmaceutical Fund, LP - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 2,324,734 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 0 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 2,324,734 Person ------------------------------------------------- 8. Shared Dispositive Power: 0 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: PN - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 3 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person Perseus-Soros Partners, LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 2,324,734 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 0 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 2,324,734 Person ------------------------------------------------- 8. Shared Dispositive Power: 0 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: OO - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 4 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person Perseus BioTech Fund Partners, LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: OO - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 5 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person SFM Participation, L.P. - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: PN - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 6 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person SFM AH LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: OO - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 7 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person Perseuspur, LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: OO - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 8 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person Frank H. Pearl - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: United States - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: IN - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 9 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person George Soros - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: United States - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: IA - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 10 of 24 - -------------------------------------------------------------------------------- 1. Name of Reporting Person. I.R.S. Identification No. of Above Person Soros Fund Management LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box if a Member of a Group: (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3. SEC Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization: Delaware - -------------------------------------------------------------------------------- 5. Sole Voting Power: 0 Number of shares ------------------------------------------------- Beneficially 6. Shared Voting Power: 2,324,734 Owned By Each ------------------------------------------------- Reporting 7. Sole Dispositive Power: 0 Person ------------------------------------------------- 8. Shared Dispositive Power: 2,324,734 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person: 2,324,734 - -------------------------------------------------------------------------------- 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares: [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row (9): 9.6% - -------------------------------------------------------------------------------- 12. Type of Reporting Person: OO; IA - -------------------------------------------------------------------------------- CUSIP NO. 06850R108 Schedule 13G Page 11 of 24 Item 1. (a) NAME OF ISSUER Barrier Therapeutics, Inc. (the "Company"). (b) ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES 600 College Road East, Suite 3200 Princeton, New Jersey 08540 Item 2. (a) NAMES OF PERSONS FILING This Statement is being filed on behalf of each of the following persons (collectively, the "Reporting Persons") (i) Perseus-Soros BioPharmaceutical Fund, LP, a Delaware limited partnership ("Perseus-Soros"); (ii) Perseus-Soros Partners, LLC, a Delaware limited liability company ("PSP GP" and general partner of Perseus-Soros); (iii) Perseus BioTech Fund Partners, LLC, a Delaware limited liability company ("PBFP Partners" and managing member of PSP GP); (iv) SFM Participation, L.P., a Delaware limited partnership ("SFM Participation" and managing member of PSP GP); (v) SFM AH LLC, a Delaware limited liability company ("SFM AH" and general partner of SFM Participation); (vi) Perseuspur, LLC, a Delaware limited liability company ("Perseuspur" and managing member of PBFP Partners); (vii) Mr. Frank H. Pearl ("Mr. Pearl" and sole member of Perseuspur); (viii) Mr. George Soros ("Mr. Soros" and Chairman of SFM LLC); and (ix) Soros Fund Management LLC, a Delaware limited liability company ("SFM LLC" and the sole managing member of SFM AH). CUSIP NO. 06850R108 Schedule 13G Page 12 of 24 (b) ADDRESS OF PRINCIPAL BUSINESS OFFICE The address of the principal business offices of Perseus-Soros is 888 Seventh Avenue, 30th Floor, New York, NY 10106. The address of the principal business offices of (i) PSP GP, (ii) PBFP Partners, (iii) Perseuspur and (iv) Mr. Pearl is 2099 Pennsylvania Ave., N.W., Suite 900, Washington, D.C. 20006. The address of the principal business offices of (i) SFM Participation, (ii) SFM AH, (iii) SFM LLC and (iv) Mr. Soros is 888 Seventh Avenue, 33rd Floor, New York, NY 10106. (c) CITIZENSHIP (i) Perseus-Soros - a Delaware limited partnership (ii) PSP GP - a Delaware limited liability company (iii) PBFP Partners - a Delaware limited liability company (iv) SFM Participation - a Delaware limited partnership (v) SFM AH - a Delaware limited liability company (vi) Perseuspur - Delaware limited liability company (vii) Mr. Pearl - United States (viii) Mr. Soros - United States (ix) SFM LLC - a Delaware limited liability company (d) TITLE OF CLASS OF SECURITIES Common Stock, par value $.0001 per share (the "Common Stock" or "Shares") (e) CUSIP NUMBER 06850R108 Information contained herein concerning SFM Participation, SFM AH, SFM LLC and Mr. Soros has been provided by SFM LLC. Perseus-Soros, PSP GP, PBFP Partners, Perseuspur and Mr. Pearl assume no responsibility for such information. Information contained herein concerning PBFP Partners, Perseuspur and Mr. Pearl has been provided by each such Reporting Person. Perseus-Soros, PSP GP, SFM Participation, SFM AH, SFM LLC and Mr. Soros assume no responsibility for such information. CUSIP NO. 06850R108 Schedule 13G Page 13 of 24 Item 3. This statement is not being filed pursuant to either Rule 13d-1(b) or 13d-2(b) or (c). Item 4. OWNERSHIP. (a) AMOUNT BENEFICIALLY OWNED: Each of the Reporting Persons may be deemed to beneficially own an aggregate of 2,324,734 Shares. (b) PERCENTAGE OWNED: Based on calculations made in accordance with Rule 13d-3(d), and there being 24,093,875 Shares outstanding as of November 8, 2005, each of the Reporting Persons may be deemed to beneficially own approximately 9.6% of the outstanding Common Stock. (c) NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS: (i) Each of Perseus-Soros and PSP GP may be deemed to have sole power to direct the voting and disposition of the 2,324,734 Shares beneficially owned by Perseus-Soros. (ii) By virtue of the relationships between and among the Reporting Persons as described in Item 2, each of the Reporting Persons, other than Perseus-Soros and PSP GP, may be deemed to share the power to direct the voting and disposition of the 2,324,734 Shares beneficially owned by Perseus-Soros. Item 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS Not applicable. Item 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON The partners of Perseus-Soros have the right to participate in the receipt of dividends from, or proceeds from the sale of, the securities held for the account of Perseus-Soros in accordance with their ownership interests in Perseus-Soros. Item 7. IDENTIFICATION AND CLASSIFICATION OF SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY Not applicable. CUSIP NO. 06850R108 Schedule 13G Page 14 of 24 Item 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP Not applicable. Item 9. NOTICE OF DISSOLUTION OF GROUP Not applicable. Item 10. CERTIFICATION Not applicable. [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] CUSIP NO. 06850R108 Schedule 13G Page 15 of 24 SIGNATURES After reasonable inquiry and to the best of our knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. Dated as of February 14, 2006 PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP By: Perseus-Soros Partners, LLC General Partner By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel CUSIP NO. 06850R108 Schedule 13G Page 16 of 24 PERSEUS-SOROS PARTNERS, LLC By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel PERSEUS BIOTECH FUND PARTNERS, LLC By: Perseuspur, LLC Managing Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer CUSIP NO. 06850R108 Schedule 13G Page 17 of 24 SFM PARTICIPATION, L.P. By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel SFM AH LLC By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel PERSEUSPUR, LLC By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer MR. FRANK H. PEARL By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Attorney-in-Fact (1) CUSIP NO. 06850R108 Schedule 13G Page 18 of 24 MR. GEORGE SOROS By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Attorney-in-Fact (2) SOROS FUND MANAGEMENT LLC By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel (1) A Power of Attorney, dated April 9, 2003, appointing Rodd Macklin to act on behalf of Frank Pearl has been filed with the Securities and Exchange Commission. (2) A Power of Attorney, dated June 16, 2005, appointing each of Armando T. Belly, Jodye Anzalotta, Maryann Canfield, Jay Schoenfarber and Robert Soros to act on behalf of George Soros has been filed with the Securities and Exchange Commission. CUSIP NO. 06850R108 Schedule 13G Page 19 of 24 EXHIBIT INDEX Exhibit 1. Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended. Exhibit 2. Power of Attorney, dated June 16, 2005 appointing each of Armando T. Belly, Jodye Anzalotta, Maryann Canfield, Jay Schoenfarber and Robert Soros as Attorney-In-Fact for George Soros. Exhibit 3. Power of Attorney, dated April 9, 2003, appointing Rodd Macklin as Attorney-in-Fact for Frank H. Pearl. EX-99 2 ex-1sc13ga1_barrier.txt EXHIBIT 1 CUSIP NO. 06850R108 Schedule 13G Page 20 of 24 EXHIBIT 1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate. Dated as of February 14, 2006 PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP By: Perseus-Soros Partners, LLC General Partner By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel CUSIP NO. 06850R108 Schedule 13G Page 21 of 24 PERSEUS-SOROS PARTNERS, LLC By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel PERSEUS BIOTECH FUND PARTNERS, LLC By: Perseuspur, LLC Managing Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer SFM PARTICIPATION, L.P. By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel CUSIP NO. 06850R108 Schedule 13G Page 22 of 24 SFM AH LLC By: Soros Fund Management LLC Managing Member By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel PERSEUSPUR, LLC By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer MR. FRANK H. PEARL By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Attorney-in-Fact (1) MR. GEORGE SOROS By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Attorney-in-Fact (2) SOROS FUND MANAGEMENT LLC By: /s/ Jodye Anzalotta --------------------------------------- Name: Jodye Anzalotta Title: Assistant General Counsel (1) A Power of Attorney, dated April 9, 2003, appointing Rodd Macklin to act on behalf of Frank Pearl has been filed with the Securities and Exchange Commission. (2) A Power of Attorney, dated June 16, 2005, appointing each of Armando T. Belly, Jodye Anzalotta, Maryann Canfield, Jay Schoenfarber and Robert Soros to act on behalf of George Soros has been filed with the Securities and Exchange Commission. EX-24 3 ex-2sc13ga1_barrier.txt EXHIBIT 2 CUSIP NO. 06850R108 Schedule 13G Page 23 of 24 EXHIBIT 2 POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENT, that I, GEORGE SOROS, hereby make, constitute and appoint each of ARMANDO T. BELLY, JODYE ANZALOTTA, MARYANN CANFIELD, JAY SCHOENFARBER and ROBERT SOROS, acting individually, as my agent and attorney-in-fact for the purpose of executing in my name, (a) in my personal capacity or (b) in my capacity as Chairman of, member of or in other capacities with Soros Fund Management LLC ("SFM LLC") and each of its affiliates or entities advised by me or SFM LLC, all documents, certificates, instruments, statements, filings and agreements ("documents") to be filed with or delivered to any foreign or domestic governmental or regulatory body or required or requested by any other person or entity pursuant to any legal or regulatory requirement relating to the acquisition, ownership, management or disposition of securities, futures contracts or other investments, and any other documents relating or ancillary thereto, including without limitation all documents relating to filings with the Commodity Futures Trading Commission and National Futures Association, the United States Securities and Exchange Commission (the "SEC") pursuant to the Securities Act of 1933 or the Securities Exchange Act of 1934 (the "Act") and the rules and regulations promulgated thereunder, including all documents relating to the beneficial ownership of securities required to be filed with the SEC pursuant to Section 13(d) or Section 16(a) of the Act and any information statements on Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act. All past acts of these attorneys-in-fact in furtherance of the foregoing are hereby ratified and confirmed. Execution of this power of attorney revokes that certain Power of Attorney dated as of the 11th March 2005 with respect to the same matters addressed above. This power of attorney shall be valid from the date hereof until revoked by me. IN WITNESS WHEREOF, I have executed this instrument as of the 16th day of June 2005. GEORGE SOROS /s/ Daniel Eule ------------------------------ Name: Daniel Eule Title: Attorney-in-Fact EX-24 4 ex-3sc13ga1_barrier.txt EXHIBIT 3 CUSIP NO. 06850R108 Schedule 13G Page 24 of 24 EXHIBIT 3 POWER OF ATTORNEY KNOW ALL BY THESE PRESENTS, that I, FRANK H. PEARL, hereby make, constitute and appoint RODD MACKLIN as my agent and attorney-in-fact for the purpose of executing in my name, (a) in my personal capacity or (b) in my capacity as Chairman of, member of or in other capacities with Perseus LLC ("PERSEUS") and each of its affiliates or entities advised by me or Perseus, all documents, certificates, instruments, statements, filings and agreements ("DOCUMENTS") to be filed with or delivered to any foreign or domestic governmental or regulatory body or required or requested by any other person or entity pursuant to any legal or regulatory requirement relating to the acquisition, ownership, management or disposition of securities, futures contracts, or other investments, and any other documents relating or ancillary thereto, including but not limited to, all documents relating to filings with the Commodities Futures Trading Commission and National Futures Association, the United States Securities and Exchange Commission (the "SEC") pursuant to the Commodities Exchange Act and the Securities Act of 1933 or the Securities Exchange Act of 1934 (the "Act") and the rules and regulations promulgated thereunder, including all documents relating to the beneficial ownership of securities required to be filed with the SEC pursuant to Section 13(d) or Section 16(a) of the Act and information statements on Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act. All past acts of the attorney-in-fact in furtherance of the foregoing are hereby ratified and confirmed. This power of attorney shall be valid from the date hereof until revoked by me. IN WITNESS WHEREOF, I have executed this instrument as of the 9th day of April, 2003. /s/ Frank H. Pearl ----------------------------- FRANK H. PEARL -----END PRIVACY-ENHANCED MESSAGE-----